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ecg recording bioamp  (ADInstruments)

 
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    ADInstruments ecg recording bioamp
    Ecg Recording Bioamp, supplied by ADInstruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ecg recording bioamp/product/ADInstruments
    Average 90 stars, based on 1 article reviews
    ecg recording bioamp - by Bioz Stars, 2026-04
    90/100 stars

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    Experimental setup. (A) Layout of mouse organs susceptible to translation inhibitors. Organs marked in green are permeable for both harringtonine and cy-cloheximide within 15 sec post-injection. Translation elongation rate can be directly measured in these organs. Testes (shown in yellow) are partially permeable, and brain is mostly unaffected by inhibitors. (B) High doses of harringtonine severely drop heartbeat rate. We established that 2.5 mg/ml had no effect on the beat rate, whereas 5 mg/ml decreased it twice. 10 mg/ml caused cardiac arrest in most of the cases. All injections were done in a tail vein - injection volume was 200 μ l and the weight of mice was 20-25 g. (C) Representative <t>electrocardiograms</t> <t>(ECG)</t> from injected mice. The upper track shows the slowdown of the beat rate in response to 5 mg/ml harringtonine. The lower track shows no difference after the injection of 2.5 mg/ml harringtonine. The effect of harringtonine appears roughly 20 sec after the injection. The red line marks the injection event.
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    Experimental setup. (A) Layout of mouse organs susceptible to translation inhibitors. Organs marked in green are permeable for both harringtonine and cy-cloheximide within 15 sec post-injection. Translation elongation rate can be directly measured in these organs. Testes (shown in yellow) are partially permeable, and brain is mostly unaffected by inhibitors. (B) High doses of harringtonine severely drop heartbeat rate. We established that 2.5 mg/ml had no effect on the beat rate, whereas 5 mg/ml decreased it twice. 10 mg/ml caused cardiac arrest in most of the cases. All injections were done in a tail vein - injection volume was 200 μ l and the weight of mice was 20-25 g. (C) Representative <t>electrocardiograms</t> <t>(ECG)</t> from injected mice. The upper track shows the slowdown of the beat rate in response to 5 mg/ml harringtonine. The lower track shows no difference after the injection of 2.5 mg/ml harringtonine. The effect of harringtonine appears roughly 20 sec after the injection. The red line marks the injection event.
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    Experimental setup. (A) Layout of mouse organs susceptible to translation inhibitors. Organs marked in green are permeable for both harringtonine and cy-cloheximide within 15 sec post-injection. Translation elongation rate can be directly measured in these organs. Testes (shown in yellow) are partially permeable, and brain is mostly unaffected by inhibitors. (B) High doses of harringtonine severely drop heartbeat rate. We established that 2.5 mg/ml had no effect on the beat rate, whereas 5 mg/ml decreased it twice. 10 mg/ml caused cardiac arrest in most of the cases. All injections were done in a tail vein - injection volume was 200 μ l and the weight of mice was 20-25 g. (C) Representative electrocardiograms (ECG) from injected mice. The upper track shows the slowdown of the beat rate in response to 5 mg/ml harringtonine. The lower track shows no difference after the injection of 2.5 mg/ml harringtonine. The effect of harringtonine appears roughly 20 sec after the injection. The red line marks the injection event.

    Journal: bioRxiv

    Article Title: Organ-specific translation elongation rates measured by in vivo ribosome profiling

    doi: 10.1101/279257

    Figure Lengend Snippet: Experimental setup. (A) Layout of mouse organs susceptible to translation inhibitors. Organs marked in green are permeable for both harringtonine and cy-cloheximide within 15 sec post-injection. Translation elongation rate can be directly measured in these organs. Testes (shown in yellow) are partially permeable, and brain is mostly unaffected by inhibitors. (B) High doses of harringtonine severely drop heartbeat rate. We established that 2.5 mg/ml had no effect on the beat rate, whereas 5 mg/ml decreased it twice. 10 mg/ml caused cardiac arrest in most of the cases. All injections were done in a tail vein - injection volume was 200 μ l and the weight of mice was 20-25 g. (C) Representative electrocardiograms (ECG) from injected mice. The upper track shows the slowdown of the beat rate in response to 5 mg/ml harringtonine. The lower track shows no difference after the injection of 2.5 mg/ml harringtonine. The effect of harringtonine appears roughly 20 sec after the injection. The red line marks the injection event.

    Article Snippet: Heart function was monitored by ECG (AD Instruments, Powerlab 8/30 recorder with BioAmp electrodes).

    Techniques: Injection

    Measuring translation elongation rate in vivo . (A) ECG monitoring of heart function before and after drug injection to ensure the heart beat rate is unaffected at the chosen dosage. (B) Experimental design for a time-resolved study. (C) Linear regression analysis of injection timepoints to infer the elongation rate. (D) Comparison of mean translation elongation rates in three organs. (E) Metagene analysis of ribosome profiling sequences. Genes longer than 2,000 nucleotides are presented. The first 1,500 nucleotides are shown starting from the first codon of the reading frame. Solid lines represent mean signal from biological replicates, and light shading corresponds to a standard deviation.

    Journal: bioRxiv

    Article Title: Organ-specific translation elongation rates measured by in vivo ribosome profiling

    doi: 10.1101/279257

    Figure Lengend Snippet: Measuring translation elongation rate in vivo . (A) ECG monitoring of heart function before and after drug injection to ensure the heart beat rate is unaffected at the chosen dosage. (B) Experimental design for a time-resolved study. (C) Linear regression analysis of injection timepoints to infer the elongation rate. (D) Comparison of mean translation elongation rates in three organs. (E) Metagene analysis of ribosome profiling sequences. Genes longer than 2,000 nucleotides are presented. The first 1,500 nucleotides are shown starting from the first codon of the reading frame. Solid lines represent mean signal from biological replicates, and light shading corresponds to a standard deviation.

    Article Snippet: Heart function was monitored by ECG (AD Instruments, Powerlab 8/30 recorder with BioAmp electrodes).

    Techniques: In Vivo, Injection, Comparison, Standard Deviation